Survivin: a unique target for tumor therapy
نویسندگان
چکیده
منابع مشابه
Survivin as a Preferential Target for Cancer Therapy
Cancer is typically a consequence of imbalance between cell death and proliferation in a way favorable to cell proliferation and survival. Most conventional cancer therapies are based on targeting rapidly growing cancerous cells to block growth or enhance cell death, thereby, restoring the balance between these processes. In many instances, malignancies that develop resistance to current treatm...
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Expression of survivin is elevated in most malignancies, especially in radiation-resistant cell lines. In this study, we investigated how radiation affects survivin expression in primary endothelial cells as well as in malignant cell lines. We found that 3 Gy significantly reduced survivin protein level in human umbilical vein endothelial cells (HUVECs) but not in tumor cell lines. Flow cytomet...
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ژورنال
عنوان ژورنال: Cancer Cell International
سال: 2016
ISSN: 1475-2867
DOI: 10.1186/s12935-016-0326-1